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There are 3 four-letter words containing XO

AXONaxon n. (Cytology) A nerve fibre which is a long slender projection of a nerve cell, and which conducts nerve…
AXON n. (Greek) a nerve fibre, also AXONE.
EXONexon n. An officer of the Queen’s Body Guard of the Yeomen of the Guard.
exon n. (Genetics) A region of a transcribed gene present in the final functional RNA molecule.
Exon prop.n. A surname.
MYXOmyxo n. (Informal) myxomatosis, a rabbit disease transmitted by mosquitoes and fleas.
myxo- pref. Mucus.
MYXO n. (Australian slang) myxomatosis, a disease introduced to control rabbits.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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