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There are 2 seven-letter words containing VACUO

VACUOLEvacuole n. (Cytology) A large membrane-bound vesicle in a cell’s cytoplasm.
vacuole n. A small empty or air-filled space or vacuity.
VACUOLE n. a small cavity in organic tissue.
VACUOUSvacuous adj. Empty; void; lacking meaningful content.
vacuous adj. Showing a lack of thought or intelligence; vacant.
VACUOUS adj. empty.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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