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There are 3 eight-letter words containing UPTU

RUPTUREDruptured adj. Having a rupture; broken, leaking.
ruptured v. Simple past tense and past participle of rupture.
RUPTURE v. to burst.
RUPTURESruptures n. Plural of rupture.
ruptures v. Third-person singular simple present indicative form of rupture.
RUPTURE v. to burst.
UPTURNEDupturned adj. Turned over; inverted; capsized.
upturned adj. (Of a nose etc.) turned up at the end.
upturned adj. Looking upwards, turned upwards.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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