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There are 2 eight-letter words containing UPEP

EUPEPSIAeupepsia n. Good digestion.
EUPEPSIA n. a good digestion, also EUPEPSY.
EUPEPTICeupeptic adj. Having or relating to good digestion.
eupeptic adj. Cheerful.
EUPEPTIC adj. relating to or having good digestion; cheerful.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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