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There are 10 eight-letter words containing UCLE

BOUCLEESBOUCLEE n. (French) a loop made with forefinger and thumb to guide a billiard stick.
NUCLEASEnuclease n. (Biochemistry) Any of several enzymes capable of cleaving the phosphodiester bonds between the nucleotide…
NUCLEASE n. any of a number of enzymes producing hydrolysis in nucleic acids.
NUCLEATEnucleate adj. Having a nucleus; nucleated.
nucleate v. To form (into) a nucleus, or to act as a nucleus.
nucleate n. Any salt of a nucleic acid.
NUCLEIDEnucleide n. Alternative form of nuclide.
NUCLEIDE n. an atom of specified atomic number and mass number, also NUCLIDE.
NUCLEINSnucleins n. Plural of nuclein.
NUCLEIN n. a protein found in cell nuclei.
NUCLEOIDnucleoid n. (Microbiology) The irregularly-shaped region within a prokaryote cell where the genetic material is localized.
NUCLEOID n. the DNA-containing area of certain cells.
NUCLEOLEnucleole n. Alternative form of nucleolus.
NUCLEOLE n. a minute rounded body within the nucleus of a cell, associated with RNA synthesis, also NUCLEOLUS.
NUCLEOLInucleoli n. Plural of nucleolus.
NUCLEOLUS n. a minute rounded body within the nucleus of a cell, associated with RNA synthesis, also NUCLEOLE.
NUCLEONSnucleons n. Plural of nucleon.
NUCLEON n. a general name for a neutron or proton.
RAUCLESTRAUCLE adj. (Scots) rough, vigorous.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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