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There are 7 eight-letter words containing UPO

ACUPOINTacupoint n. (Alternative medicine) A specific point on the body where acupuncture or acupressure is applied.
ACUPOINT n. an acupuncture site.
CROUPONScroupons n. Plural of croupon.
CROUPON n. the human buttocks.
CROUPOUScroupous adj. (Medicine) Relating to or resembling croup; especially, attended with the formation of a deposit or…
CROUPOUS adj. pertaining to croup.
CUPOLAEDcupolaed adj. Having one or more cupolas.
CUPOLA v. to furnish with a cupola.
DUPONDIIdupondii n. Plural of dupondius.
DUPONDIUS n. an old Roman coin.
GROUPOIDgroupoid n. (Algebra) A magma: a set with a total binary operation.
groupoid n. (Algebra and category theory) A set with a partial binary operation that is associative and has identities…
GROUPOID n. a type of mathematical set.
HEREUPONhereupon adv. Immediately afterwards; at this.
HEREUPON adv. immediately following this.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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