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There are 4 four-letter words containing UPA

OUPA	• OUPA n. (South African) a grandfather, also OPA.
PUPA	• pupa n. An insect in the development stage between larva and adult. • pupa n. Used as a specific epithet; resembling an insect in its pupal stage of development. • Pupa prop.n. A taxonomic genus within the family Acteonidae – certain small sea snails.
UPAS	• upas n. (Usually countable) A tree, Antiaris toxicaria, of the mulberry family, common in the forests of Java… • upas n. (Uncountable) A virulent poison used in Java and the adjacent islands for poisoning arrows derived from the tree. • upas n. (Uncountable) A poison prepared from the climbing plant Strychnos tieute.
ZUPA	• zupa n. An administrative unit among various South Slavic peoples. • ZUPA n. (Serbo-Croat) in early Serbia, a confederation of villages, governed by a zupan.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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English Wiktionary: 8 words
Scrabble in French: 4 words
Scrabble in Spanish: 9 words
Scrabble in Italian: 4 words
Scrabble in German: no word
Scrabble in Romanian: 9 words

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