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There are 14 two-letter words containing U

GUgu n. Alternative spelling of gue (“Shetland fiddle”).
gu n. (Heraldry) Abbreviation of gules.
gu sym. (International standards) ISO 639-1 language code for Gujarati.
MUmu n. The 12th letter of the Modern Greek alphabet.
mu interj. (Zen Buddhism) Neither yes nor no.
mu n. (Zen Buddhism) Nothingness; nonexistence; the illusory nature of reality.
NUnu n. The letter of the Greek alphabet Ν and ν.
nu n. A measure of constringence in lenses or prisms.
nu interj. (Jewish) An exclamation of surprise, emphasis, doubt, etc.
OUou n. A probably extinct species of Hawaiian honeycreeper, Psittirostra psittacea.
ou n. (South Africa, colloquial) A fellow, guy, bloke.
OU prop.n. Initialism of Open University.
UGug n. (Northern England and Scotland, obsolete) A feeling of fear, horror or disgust.
ug n. (Northern England and Scotland, obsolete) An object of disgust.
ug n. (Northern England and Scotland, obsolete) Vomited matter.
UHuh interj. Expression of thought, confusion, or uncertainty.
uh interj. Space filler or pause during conversation.
uh n. An occurrence of the interjection "uh".
UMum interj. Expression of hesitation, uncertainty or space filler in conversation. See uh.
um interj. (Chiefly US) Dated spelling of mmm.
um v. (Intransitive) To make the um sound to express uncertainty or hesitancy.
UNun n. Alternative spelling of ’un.
Un prop.n. A surname.
UN prop.n. Initialism of United Nations.
UPup adv. Away from the surface of the Earth or other planet; in opposite direction to the downward pull of gravity.
up adv. To or at a physically higher or more elevated position.
up adv. To a higher level of some quantity or notional quantity, such as price, volume, pitch, happiness, etc.
URur interj. Expressing hesitation or inarticulacy; er, um.
ur det. (Informal, Internet, text messaging) Abbreviation of your.
ur cont. (Informal, Internet, text messaging) Abbreviation of you’re (you are).
USus pron. (Personal) Me and at least one other person; the objective case of we.
us pron. (Commonwealth, colloquial, chiefly with give) Me.
us pron. (Northern England) Our.
UTut n. (Music, dated) Syllable (formerly) used in solfège to represent the first note of a major scale.
UT prop.n. Abbreviation of Utah, a state of the United States of America.
UT prop.n. Initialism of University of Texas, Austin TX.
XUxu n. A minor unit of currency in Vietnam, now little-used, forming a hundredth of a dong.
Xu prop.n. A Chinese surname from Mandarin from 徐 or 許.
ǃXũ prop.n. A Northern Khoisan language of Namibia, Angola, and Botswana. This language has about 5,000 speakers…
YUyu n. (Archaeology, countable) An ancient Chinese wine-bucket, often having a decorative cover.
yu n. (Archaic, uncountable) Jade, nephrite or jadeite.
yu pron. Eye dialect spelling of you.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org.

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