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There are 3 twelve-letter words containing TUPEFAC

STUPEFACIENTstupefacient adj. (Medicine) Inducing stupor or drowsiness (with a drug such as a narcotic or an anaesthetic).
stupefacient n. (Medicine) Any drug that induces stupor or drowsiness.
STUPEFACIENT n. a narcotic, a stupefying drug.
STUPEFACTIONstupefaction n. The state of extreme shock or astonishment.
stupefaction n. A state of insensibility; stupor.
STUPEFACTION n. the act of stupefying.
STUPEFACTIVEstupefactive adj. Inducing stupor; making drowsy; stupefacient.
STUPEFACTIVE adj. causing stupefaction.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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