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There are 2 eight-letter words containing TOTO

AUTOTOMYautotomy n. (Chiefly zoology) The spontaneous removal of a limb, tail etc, especially by some invertebrates as a…
AUTOTOMY n. the reflex loss of part of the body to save the whole (in lizards, etc.).
OTOTOXICototoxic adj. Causing ototoxicity.
OTOTOXIC adj. adversely affecting hearing or balance.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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