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There are 4 eight-letter words containing TOPE

AUTOPENSautopens n. Plural of autopen.
AUTOPEN n. a mechanical device used to produce imitation signatures.
BIOTOPESbiotopes n. Plural of biotope.
BIOTOPE n. an area having uniform conditions and supporting a particular, uniform association of animal life.
EPITOPESepitopes n. Plural of epitope.
EPITOPE n. a part of an antigen complementary to an antibody.
ISOTOPESisotopes n. Plural of isotope.
ISOTOPE n. one of two more atoms with the same atomic number that contain different numbers of neutrons.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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