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There are 12 eight-letter words containing SPIRE

ASPIRERSaspirers n. Plural of aspirer.
ASPIRER n. one who aspires.
CONSPIREconspire v. (Intransitive) To secretly plot or make plans together, often with the intention to bring bad or illegal results.
conspire v. (Intransitive) To agree, to concur to one end.
conspire v. (Transitive) To work together to bring about.
INSPIREDinspired adj. Having excellence through inspiration.
inspired adj. Filled with inspiration or motivated.
inspired adj. (Religion) Infused with power or knowledge granted from a supernatural entity; possessing inspiration from the divine.
INSPIRERinspirer n. Someone who inspires.
INSPIRER n. one that inspires.
INSPIRESinspires v. Third-person singular simple present indicative form of inspire.
INSPIRE v. to influence to greater heights.
PERSPIREperspire v. (Transitive, intransitive) To emit (sweat or perspiration) through the skin’s pores.
perspire v. (Intransitive) To be evacuated or excreted, or to exude, through the pores of the skin.
PERSPIRE v. to exude sweat through the pores of the skin.
RESPIREDrespired v. Simple past tense and past participle of respire.
RESPIRE v. to breathe.
RESPIRESrespires v. Third-person singular simple present indicative form of respire.
RESPIRE v. to breathe.
SPIRELETspirelet n. (Architecture) A small or slender spire.
SPIRELET n. a slender spire.
SPIREMESspiremes n. Plural of spireme.
SPIREME n. a filament forming part of a cell nucleus, also SPIREM.
SUSPIREDsuspired v. Simple past tense and past participle of suspire.
suspired adj. (Obsolete) Ardently desired or longed for; earnestly coveted.
SUSPIRE v. to sigh.
SUSPIRESsuspires v. Third-person singular simple present indicative form of suspire.
SUSPIRE v. to sigh.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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