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There are 12 six-letter words containing SIGN

ASSIGNassign v. (Transitive) To designate or set apart (something) for some purpose.
assign v. (Transitive) To appoint or select (someone) for some office.
assign v. (Transitive) To allot or give (something) as a task.
COSIGNcosign v. To sign a document jointly with another person, sometimes as an endorsement.
cosign v. (Slang) To agree with or endorse.
cosign n. The promotion of one musical artist (usually less successful) by another.
DESIGNdesign n. A specification of an object or process, referring to requirements to be satisfied and thus conditions…
design n. A plan (with more or less detail) for the structure and functions of an artifact, building or system.
design n. A pattern, as an element of a work of art or architecture.
ENSIGNensign n. A badge of office, rank, or power.
ensign n. The lowest grade of commissioned officer in the United States Navy, junior to a lieutenant junior grade.
ensign n. A flag or banner carried by military units; a standard or color/colour.
OBSIGNobsign v. (Obsolete) To seal; to confirm, as by a seal or stamp.
OBSIGN v. to seal or confirm, also OBSIGNATE.
RESIGNresign v. (Transitive) To give up; to relinquish ownership of.
resign v. (Transitive) To hand over (something to someone), place into the care or control of another.
resign v. (Transitive or intransitive) To quit (a job or position).
SIGNALsignal n. A sequence of states representing an encoded message in a communication channel.
signal n. Any variation of a quantity or change in an entity over time that conveys information upon detection.
signal n. A sign made to give notice of some occurrence, command, or danger, or to indicate the start of a concerted action.
SIGNEDsigned adj. Having a signature; endorsed.
signed adj. (Mathematics, computer science) Having both positive and negative varieties.
signed adj. (Of a road, route) Furnished with signs and signposts; signposted.
SIGNEEsignee n. One who signs a contract, especially in athletic contexts.
SIGNEE n. a signer of a document.
SIGNERsigner n. One who signs something.
signer n. One who uses sign language.
SIGNER n. one that signs.
SIGNETsignet n. An object (especially a ring) formerly used to impress a picture into the sealing wax of a document…
SIGNET v. to mark with an official seal.
SIGNORsignor n. A courtesy title for a man of Italian origin.
SIGNOR n. (Italian) an Italian title of courtesy for a man, also SIGNIOR, SIGNORE.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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