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There are 15 twelve-letter words containing STIO

DECONGESTIONdecongestion n. The process of decongesting something.
DECONGESTION n. the process of relieving congestion.
DEMIBASTIONSdemibastions n. Plural of demibastion.
DEMIBASTION n. half a bastion, having only one flank, at right angles to the wall.
HISTIOLOGIESHISTIOLOGY n. the study of the tissues of organisms, also HISTOLOGY.
INDIGESTIONSindigestions n. Plural of indigestion.
INDIGESTION n. inability to digest or difficulty in digesting something.
MOXIBUSTIONSmoxibustions n. Plural of moxibustion.
MOXIBUSTION n. cauterization by use of moxa.
PREDIGESTIONpredigestion n. The partial hydrolysis etc. of food, by enzymes or other materials, prior to normal digestion.
PREDIGESTION n. artificial or natural partial digestion of food.
QUAESTIONARYquæstionary n. Rare spelling of questionary.
QUAESTIONARY n. (Scott) a religious pardoner, also QUESTIONARY.
QUESTIONABLEquestionable adj. Problematic; open to doubt or challenge.
questionable adj. Of dubious respectability or morality.
questionable adj. (Obsolete) Inviting questions; inviting inquiry.
QUESTIONABLYquestionably adv. In a questionable manner.
QUESTIONABLE adv. open to question.
QUESTIONINGSquestionings n. Plural of questioning.
QUESTIONING n. the act of questioning.
QUESTIONISTSquestionists n. Plural of questionist.
QUESTIONIST n. a questioner, a doubter.
QUESTIONLESSquestionless adj. (Rare) Certain; indubitable; unquestionable; not admitting of question or doubt.
questionless adj. Asking no questions; unquestioning.
questionless adv. (Archaic) Certainly; undoubtedly; without question.
REDIGESTIONSredigestions n. Plural of redigestion.
REDIGESTION n. the act of redigesting.
ROBUSTIOUSLYrobustiously adv. In a robustious manner.
ROBUSTIOUS adv. boisterous.
UNQUESTIONEDunquestioned adj. (Of a person) Not subjected to an interrogation.
unquestioned adj. (Of a fact) Accepted without question; indisputable.
UNQUESTIONED adj. not questioned.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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