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There are 3 ten-letter words containing SPIS

DESPISABLEdespisable adj. (Archaic) Worthy to be despised.
DESPISABLE adj. despicable; contemptible.
INSPISSATEinspissate v. (Transitive) To thicken a fluid, in the sense of making it more viscous, especially by boiling, evaporation…
inspissate v. (Intransitive) Of a fluid: to become more viscous.
INSPISSATE v. to make thick.
SPISSITUDEspissitude n. (Of liquids) Density, thickness; the state or quality of being inspissated or thickened.
spissitude n. Spiritual substance or density, viewed as the fourth dimension of an object.
SPISSITUDE n. density.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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