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There are 16 eight-letter words containing SOF

ISOFORMSisoforms n. Plural of isoform.
ISOFORM n. one of two or more proteins having a similar form.
OVERSOFToversoft adj. Too soft; too quiet.
OVERSOFT adj. excessively soft.
RESOFTENresoften v. To soften again.
RESOFTEN v. to soften again.
SEMISOFTsemisoft adj. (Especially of food) Partially soft; partially melted.
semisoft n. (Rare) Any semisoft variety of cheese.
semi-soft adj. Alternative spelling of semisoft.
SOFABEDSsofabeds n. Plural of sofabed.
sofa-beds n. Plural of sofa-bed.
sofa␣beds n. Plural of sofa bed.
SOFFIONIsoffioni n. Plural of soffione.
SOFFIONI n. (Italian) volcanic steam-holes.
SOFTBACKsoftback n. A softcover or paperback book.
SOFTBACK n. a book bound in a flexible paper cover.
SOFTBALLsoftball n. A game similar to baseball but played with a larger and softer ball which can be thrown overhand or underhand.
softball n. The ball used to play the sport.
softball n. (By analogy) A question designed to be easy to answer.
SOFTCOREsoftcore n. Pornography that does not contain depictions of explicit sexual penetration.
softcore adj. (Slang, of music genres, subcultures, etc.) Less intense, committed or aggressive than hardcore.
soft-core adj. Alternative form of softcore.
SOFTENEDsoftened adj. Made soft.
softened adj. (Linguistics) aspirated.
softened v. Simple past tense and past participle of soften.
SOFTENERsoftener n. One who, or that which, softens.
SOFTENER n. one that softens.
SOFTHEADsofthead n. A fool; a silly or feeble-minded person.
SOFTHEAD n. a foolish person.
SOFTLINGsoftling n. (Archaic) A soft, effeminate person; a voluptuary.
SOFTLING n. (archaic) a soft, effeminate person.
SOFTNESSsoftness n. The quality of being soft.
SOFTNESS n. the state of being soft.
SOFTWAREsoftware n. (Computing) Encoded computer instructions, usually modifiable (unless stored in some form of unalterable…
software n. (Military) The human beings involved in warfare, as opposed to hardware such as weapons and vehicles.
SOFTWARE n. data used in computer operations.
SOFTWOODsoftwood n. (Countable, chiefly botany) The wood from any gymnosperm, without regard to how soft this wood is.
softwood n. (Countable, in more general use) Wood of this kind, but limited to those that are commercial timbers.
softwood n. (Countable, forestry) The tree or tree species that yields this wood.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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