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There are 13 five-letter words containing SPU

SPUDSspuds n. Plural of spud.
Spuds prop.n. (Soccer, derogatory) Tottenham Hotspur F.C.
SPUD v. to dig up with a spadelike tool.
SPUEDspued v. Simple past tense and past participle of spue.
SPUE v. (archaic) to spew.
SPUERSPUER n. one who spues, also SPEWER.
SPUESspues v. Third-person singular simple present indicative form of spue.
SPUE v. (archaic) to spew.
SPUGSSPUG n. (colloquial) a sparrow, also SPEUG, SPRUG, SPUGGY.
SPULESPULE n. (Scots) the shoulder, also SPALD, SPALLE, SPAUL, SPAULD, SPEAL.
SPUMEspume n. Foam or froth of liquid, particularly that of seawater.
spume v. To froth.
SPUME v. to foam.
SPUMYspumy adj. Frothy, emitting froth or spume.
SPUMY adj. like spume.
SPUNKspunk n. (Countable, obsolete) A spark.
spunk n. (Uncountable) Touchwood; tinder.
spunk n. (Countable, chiefly Scotland, obsolete) A piece of tinder, sometimes impregnated with sulphur; a match.
SPURNspurn v. (Transitive, intransitive) To reject disdainfully; contemn; scorn.
spurn v. (Transitive) To reject something by pushing it away with the foot.
spurn v. (Transitive) To waste; fail to make the most of (an opportunity).
SPURSspurs n. Plural of spur.
spurs v. Third-person singular simple present indicative form of spur.
Spurs prop.n. (Soccer) Tottenham Hotspur Football Club.
SPURTspurt v. (Transitive) To cause to gush out suddenly or violently in a stream or jet.
spurt v. (Intransitive) To rush from a confined place in a small stream or jet.
spurt n. A brief gush, as of liquid spurting from an orifice or a cut/wound.
SPUTAsputa n. Plural of sputum.
SPUTUM n. (Latin) thick mucus coughed up from the respiratory tract esp in certain diseases of the lungs, chest, or throat.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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