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There are 18 five-letter words containing SPO

INSPOinspo n. (Slang) Clipping of inspiration.
INSPO n. someone or something that is a source of inspiration.
SPODESPODE n. a fine china.
SPODSspods n. Plural of spod.
SPODs n. Plural of SPOD.
SPOD n. a boring, studious person.
SPOILspoil v. (Transitive, archaic) To strip (someone who has been killed or defeated) of their arms or armour.
spoil v. (Transitive, archaic) To strip or deprive (someone) of their possessions; to rob, despoil.
spoil v. (Transitive, intransitive, archaic) To plunder, pillage (A city, country etc.).
SPOKEspoke n. A support structure that connects the axle or the hub of a wheel to the rim.
spoke n. (Nautical) A projecting handle of a steering wheel.
spoke n. A rung of a ladder.
SPOOFspoof n. (Countable) An act of deception; a hoax; a joking prank.
spoof n. (Countable) A light parody.
spoof n. (Countable, Britain, historical) A drinking game in which players hold up to three (or another specified…
SPOOKspook n. (Informal) A ghost or phantom.
spook n. A hobgoblin.
spook n. (Informal) A scare or fright.
SPOOLspool n. A reel; a device around which thread, wire or cable is wound, especially a cylinder or spindle.
spool n. (Aviation) One of the rotating assemblies of a gas turbine engine, composed of one or more turbine stages…
spool n. (Computing) A temporary storage area for electronic mail, etc.
SPOOMspoom v. (Nautical) To sail briskly with the wind astern, with or without sails hoisted.
spoom n. A sorbet containing fruit juice.
SPOOM v. to scud before the wind.
SPOONspoon n. An implement for eating or serving; a scooped utensil whose long handle is straight, in contrast to a ladle.
spoon n. An implement for stirring food while being prepared; a wooden spoon.
spoon n. A measure that will fit into a spoon; a spoonful.
SPOORspoor n. The track, trail, droppings or scent of an animal.
spoor v. (Transitive) To track an animal by following its spoor.
Spoor prop.n. An occupational surname from Middle English.
SPOOTSPOOT n. the razor-shell mollusc.
SPOREspore n. A reproductive particle, usually a single cell, released by a fungus, alga, or plant that may germinate into another.
spore n. A thick resistant particle produced by a bacterium or protist to survive in harsh or unfavorable conditions.
spore v. To produce spores.
SPORKspork n. An eating utensil shaped like a spoon, the bowl of which is divided into tines like those of a fork…
spork v. (Transitive) To move or impale (Food etc.) with a spork.
SPORK n. a spoon-like shallow scoop with the addition of the tines of a fork.
SPORTsport n. (Countable) Any activity that uses physical exertion or skills competitively under a set of rules that…
sport n. (Countable) A person who exhibits either good or bad sportsmanship.
sport n. (Countable) Somebody who behaves or reacts in an admirably good-natured manner, e.g. to being teased…
SPOSHsposh n. (Archaic) soft wet ground; mud or slush.
SPOSH n. (US) slush.
SPOTSspots n. Plural of spot.
spots v. Third-person singular simple present indicative form of spot.
SPOT v. to mark with small round discolourations.
SPOUTspout n. A tube or lip through which liquid or steam is poured or discharged.
spout n. A stream of liquid.
spout n. The mixture of air and water thrown up from the blowhole of a whale.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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