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There are 3 five-letter words containing SCI

DISCIdisci n. Plural of discus.
DISCUS n. (Latin) a disc hurled in athletic competition.
FASCIfasci n. Plural of fascio.
FASCIO n. (Italian) an organized political group.
SCIONscion n. A descendant, especially a first-generation descendant of a distinguished family.
scion n. The heir to a throne.
scion n. A guardian.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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