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There are 5 four-letter words containing SPE

SPECspec n. (Colloquial) Clipping of specification.
spec n. (Colloquial) Clipping of speculation.
spec n. Clipping of specialization.
SPEDsped v. Simple past tense and past participle of speed.
sped n. (Informal, derogatory, offensive) A special education student.
SPED n. Acronym of special education.
SPEKSPEK n. blubber from a whale.
SPETspet n. (Obsolete) spittle.
spet v. To spit; to throw out.
SPET v. to spit.
SPEWspew v. (Transitive) To eject forcibly and in a stream…
spew v. (Intransitive) To be forcibly ejected.
spew v. (Transitive) To speak or write quickly and voluminously, especially words that are not worth listening to or reading.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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