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There are 12 twelve-letter words containing SAF

ASSAFOETIDASASSAFOETIDA n. an acrid gum resin with a strong smell like that of garlic, obtained from certain Asian plants, also ASAFETIDA, ASAFOETIDA, ASSAFETIDA.
DISAFFECTINGdisaffecting v. Present participle of disaffect.
DISAFFECT v. to take away the affection of; to make discontented or unfriendly.
DISAFFECTIONdisaffection n. Discontent; unrest.
disaffection n. Alienation; loss of loyalty.
DISAFFECTION n. the state of being disaffected.
DISAFFILIATEdisaffiliate v. To cease to have an affiliation (with); to take steps to break an affiliation or association.
DISAFFILIATE v. to end an affiliation.
DISAFFIRMINGdisaffirming v. Present participle of disaffirm.
DISAFFIRM v. to assert the contrary of; to contradict.
DISAFFORESTSdisafforests v. Third-person singular simple present indicative form of disafforest.
DISAFFOREST v. to clear of forest, also DISFOREST.
SAFECRACKERSsafecrackers n. Plural of safecracker.
safe-crackers n. Plural of safe-cracker.
SAFECRACKER n. one that breaks open safes to steal.
SAFECRACKINGsafecracking n. The act of defeating the security mechanisms of a safe or vault to gain access to its contents.
SAFECRACKING n. the act of breaking open a safe.
SAFEGUARDINGsafeguarding v. Present participle of safeguard.
safeguarding n. Synonym of protection.
safeguarding n. (UK, Ireland, formal) Policies and actions for the protection of children and vulnerable adults.
SAFEKEEPINGSsafekeepings n. Plural of safekeeping.
SAFEKEEPING n. the act of preserving in safety.
UNSAFENESSESUNSAFENESS n. the state of being unsafe.
VOUCHSAFINGSvouchsafings n. Plural of vouchsafing.
VOUCHSAFING n. the act of granting as a privilege or special favour.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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