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There are 6 eight-letter words containing RUNE

BRUNETTEbrunette adj. (Of hair, eyes, skin, etc.) of a dark color or tone.
brunette adj. (Of a person) having brown or black hair and, often, dark eyes and darkish or olive skin.
brunette n. A person, especially female, with brown or black hair and, often, dark eyes and darkish or olive skin.
PRUNELLAprunella n. (Botany) A member of the genus Prunella of herbaceous plants, the allheals.
prunella n. (Obsolete, medicine) Any of various diseases characterised by inflammation of the mouth or throat.
prunella n. (Now rare, historical) A smooth worsted or silk fabric, generally black, formerly used for making shoes…
PRUNELLEprunelle n. A kind of small and very acid French plum, especially when stoned and dried, from Prunus spinosa (blackthorn, sloe).
PRUNELLE n. (French) a strong silk or woollen material, formerly used for academic and clerical gowns and women's shoes, also PRUNELLA.
PRUNELLOprunello n. A species of dried plum; a prunelle.
prunello n. Alternative form of prunella (woollen material).
PRUNELLO n. (Italian) a fine kind of prune, esp. one made from a greengage.
RUNELIKErunelike adj. Resembling a rune.
RUNELIKE adj. like a rune.
UNPRUNEDunpruned adj. Not having been pruned.
UNPRUNED adj. not pruned.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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