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There is only one four-letter word containing RUI

RUINruin n. (Countable, sometimes in the plural) The remains of a destroyed or dilapidated construction, such as…
ruin n. (Uncountable) The state of being a ruin, destroyed or decayed.
ruin n. (Uncountable) Something that leads to serious trouble or destruction.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org.

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