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There are 12 six-letter words containing PIO

APIOLSapiols n. Plural of apiol.
APIOL n. an oily liquid derived from parsley.
DOPPIOdoppio adj. Having two shots of espresso.
doppio n. Two shots of espresso.
DOPPIO n. (Italian) a double measure of espresso coffee.
DUPIONdupion n. A double cocoon, made by two silkworms.
dupion n. The silk from a double cocoon.
DUPION n. (French) a coarse silk, also DOUPIONI, DOUPPIONI.
OPIOIDopioid n. A substance that has effects similar to opium.
opioid n. (Physiology) Any of the natural substances, such as an endorphin, released in the body in response to pain.
opioid n. (Pharmacology) Any of a group of synthetic compounds that exhibit similarities to the opium alkaloids…
PIOLETpiolet n. (Climbing) An ice axe/ice ax.
PIOLET n. (French) a mountain-climbing ice axe.
PIONEDpioned adj. (Nonce word) A word of disputed meaning; perhaps, abounding in marsh marigolds.
PIONED adj. (Shakespeare) perhaps trenched, perhaps overgrown with wild orchids.
PIONERpioner n. Obsolete form of pioneer (military sapper or digger).
PIONER n. (Shakespeare) a military pioneer, also PIONEER, PYONER.
PIONEYpioney n. Obsolete form of peony.
PIONEY n. a showy flower, also PEONY, PAEONY, PINY, PIONY.
PIONICpionic adj. (Physics) Of, pertaining to, or composed of pions.
PIONIC adj. relating to a pion, a pi-meson.
PIOPIOpiopio n. Either of two extinct passerine songbirds of New Zealand comprising the genus Turnagra: the North Island…
PIOPIO n. (Maori) a New Zealand thrush, thought to be extinct.
PIOTEDPIOTED adj. (Scots) pied.
PIOYESPIOYE n. (Scots) a homemade firework, also PEEOY, PIOY.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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