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There are 4 ten-letter words containing PIU

ECTROPIUMSectropiums n. Plural of ectropium.
ECTROPIUM n. an unnatural eversion of the eyelids, also ECTROPION.
ENCOLPIUMSencolpiums n. Plural of encolpium.
ENCOLPIUM n. a reliquary; a cross worn on the breast, also ENCOLPION.
ENTROPIUMSENTROPIUM n. (Greek) the inversion or turning in of the border of the eyelids, also ENTROPION.
PRINCIPIUMPRINCIPIUM n. (Latin) a first principle; element; as Newton's Principia.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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