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There are 7 twelve-letter words containing OPHIE

ABIOTROPHIES	• abiotrophies n. Plural of abiotrophy. • ABIOTROPHY n. bodily or mental loss of function or degeneration for reasons unknown.
AMYOTROPHIES	• amyotrophies n. Plural of amyotrophy. • AMYOTROPHY n. atrophy of the muscles.
AUTOTROPHIES	• autotrophies n. Plural of autotrophy. • AUTOTROPHY n. the state of being an autotroph, an organism that is able to manufacture its own food from inorganic substances.
AUXOTROPHIES	• auxotrophies n. Plural of auxotrophy. • AUXOTROPHY n. the state of being auxotrophic, requiring a specific growth substance beyond the minimum required for normal metabolism.
CACOTROPHIES	• CACOTROPHY n. bad or inadequate diet.
GYMNOSOPHIES	• GYMNOSOPHY n. deep contemplation performed while naked.
PHILOSOPHIES	• philosophies n. Plural of philosophy. • PHILOSOPHY n. all learning exclusive of technical precepts and practical arts.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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English Wiktionary: 11 words
Scrabble in French: 15 words
Scrabble in Spanish: no word
Scrabble in Italian: no word
Scrabble in German: no word
Scrabble in Romanian: no word

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