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There are 5 six-letter words containing OTIO

LOTIONlotion n. A low- to medium-viscosity topical preparation intended for application to unbroken skin.
lotion n. (Archaic) A washing, especially of the skin for the purpose of beautification.
lotion v. (Transitive) To cover or treat with a lotion.
MOTIONmotion n. (Uncountable) A state of progression from one place to another.
motion n. (Countable) A change of position with respect to time.
motion n. (Physics) A change from one place to another.
NOTIONnotion n. Mental apprehension of whatever may be known, thought, or imagined; idea, concept.
notion n. A sentiment; an opinion.
notion n. (Obsolete) Sense; mind.
OTIOSEotiose adj. Having no effect.
otiose adj. Done in a careless or perfunctory manner.
otiose adj. Reluctant to work or to exert oneself.
POTIONpotion n. A small portion or dose of a liquid which is medicinal, poisonous, or magical.
potion v. (Transitive, obsolete) To drug (someone).
POTION n. a magical elixir or medicinal drink.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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