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There are 6 five-letter words containing OPI

GOPIKgopik n. Alternative form of qapik.
GOPIK n. a monetary unit of Azerbaijan, one hundredth of a manat, also QAPIK.
OPINEopine v. (Intransitive, transitive) To have or express an opinion; to state as an opinion; to suppose, consider (that).
opine v. (Intransitive) To give one’s formal opinion (on or upon something).
opine n. (Biochemistry) Any of a class of organic compounds, derived from amino acids, found in some plant tumours.
OPINGoping v. Present participle of ope.
OPE v. to open.
OPIUMopium n. (Uncountable) A yellow-brown, addictive narcotic drug obtained from the dried juice of unripe pods of…
opium n. (By extension, countable) Anything that numbs or stupefies.
OPIUM n. an addictive narcotic.
TOPICtopic adj. Topical.
topic n. Subject; theme; a category or general area of interest.
topic n. (Internet) Discussion thread.
TOPIStopis n. Plural of topi.
TOPI n. (Hindi) a tropical pith helmet, also TOPEE.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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