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There are 4 twelve-letter words containing LEFAC

CALEFACIENTScalefacients n. Plural of calefacient.
CALEFACIENT n. a substance (e.g. mustard) that produces a sensation of warmth when applied to a part of the body.
CALEFACTIONScalefactions n. Plural of calefaction.
CALEFACTION n. the act of heating.
MALEFACTIONSmalefactions n. Plural of malefaction.
MALEFACTION n. evildoing.
MALEFACTRESSmalefactress n. A woman who violates the law or does evil; a female malefactor.
MALEFACTRESS n. a female malefactor.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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