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There are 5 twelve-letter words containing IGNIFICA

SIGNIFICANCEsignificance n. The extent to which something matters; importance.
significance n. Meaning.
SIGNIFICANCE n. something that is conveyed as a meaning often obscurely or indirectly.
SIGNIFICANCYsignificancy n. (Dated) significance.
SIGNIFICANCY n. significance.
SIGNIFICANTSsignificants n. Plural of significant.
SIGNIFICANT n. something having meaning.
SIGNIFICATESsignificates n. Plural of significate.
SIGNIFICATE n. a thing signified.
SIGNIFICATORsignificator n. One who, or that which, signifies.
significator n. (Astrology) A planet that is supposed to rule something.
significator n. (Cartomancy) A card representing a querent, question, or situation.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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