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There are 4 nine-letter words containing ISTEM

DISTEMPERdistemper n. (Veterinary medicine, pathology) A viral disease of animals, such as dogs and cats, characterised by…
distemper n. (Archaic) A disorder of the humours of the body; a disease.
distemper n. A glue-based paint.
EPISTEMICepistemic adj. Of or relating to knowledge or cognition; cognitive.
epistemic adj. Of or relating to the metaknowledge and theory of knowledge (epistemology).
EPISTEMIC adj. (Greek) relating to knowledge or the act of knowing.
MERISTEMSmeristems n. Plural of meristem.
MERISTEM n. embryonic plant tissue capable of growth by division.
MISTEMPERmistemper v. To temper ill; to disorder.
MISTEMPER v. (obsolete) to temper ill; to disorder.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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