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There are 4 eight-letter words containing ISTRE

COISTRELcoistrel n. Alternative form of custrel.
coistrel n. Alternative form of coistril.
COISTREL n. (obsolete) an inferior groom or lad employed by an esquire to carry the knight's arms and other necessaries, also COISTRIL, COYSTREL, COYSTRIL, CUSTREL.
DISTRESSdistress n. Physical or emotional discomfort, suffering, or alarm, particularly of a more acute nature.
distress n. A cause of such discomfort.
distress n. Serious danger.
MISTREATmistreat v. (Transitive) To treat someone, or something roughly or badly.
MISTREAT v. to treat badly.
MISTRESSmistress n. A woman, specifically one with great control, authority or ownership.
mistress n. A female teacher.
mistress n. The other woman in an extramarital relationship, generally including sexual relations.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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