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There are 4 eight-letter words containing ISPEN

CRISPENScrispens v. Third-person singular simple present indicative form of crispen.
CRISPEN v. to make crisp.
DISPENCEdispence v. Obsolete form of dispense.
DISPENCE v. (Spenser) to distribute, also DISPENSE.
DISPENDSdispends v. Third-person singular simple present indicative form of dispend.
DISPEND v. (obsolete) to expend, pay out.
DISPENSEdispense v. To issue, distribute, or give out.
dispense v. To apply, as laws to particular cases; to administer; to execute; to manage; to direct.
dispense v. To supply or make up a medicine or prescription.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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