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There are 4 eight-letter words containing ISONE

POISONEDpoisoned adj. (Of a living thing) Killed, paralysed, or harmed by receiving a dose of poison.
poisoned adj. Containing poison; poisonous.
poisoned adj. (Figuratively) Having a strongly negative effect; harmful.
POISONERpoisoner n. A person who poisons something or someone.
POISONER n. one who poisons.
PRISONEDprisoned v. Simple past tense and past participle of prison.
PRISON v. to imprison.
PRISONERprisoner n. A person incarcerated in a prison, while on trial or serving a sentence.
prisoner n. Any person held against their will.
prisoner n. A person who is or feels confined or trapped by a situation or a set of circumstances.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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