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There are 7 twelve-letter words containing ISTEM

CALLISTEMONSCALLISTEMON n. an Australian genus of the myrtle family, bottlebrush shrubs.
DISTEMPERATEdistemperate adj. (Obsolete) immoderate.
distemperate adj. (Obsolete) diseased; disordered.
DISTEMPERATE adj. not temperate.
DISTEMPERINGdistempering v. Present participle of distemper.
DISTEMPER v. to paint or colour with distemper, also DESTEMPER.
EPISTEMOLOGYepistemology n. (Uncountable) The branch of philosophy dealing with the study of knowledge; theory of knowledge, asking…
epistemology n. (Countable) A particular instance, version, or school thereof; a particular theory of knowledge.
EPISTEMOLOGY n. the branch of philosophy that deals with the nature of knowledge.
MERISTEMATICmeristematic adj. Of or pertaining to the meristem.
MERISTEMATIC adj. of or like a meristem.
MISTEMPERINGmistempering v. Present participle of mistemper.
MISTEMPER v. (obsolete) to temper ill; to disorder.
MULTISTEMMEDmultistemmed adj. Having multiple stems.
MULTISTEMMED adj. having many stems.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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