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There are 3 ten-letter words containing ISTEM

DISTEMPERSdistempers v. Third-person singular simple present indicative form of distemper.
DISTEMPER v. to paint or colour with distemper, also DESTEMPER.
EPISTEMICSepistemics n. (Plural in form and plural in construction) The epistemic factors or attributes (of something).
epistemics n. (Plural in form and plural or singular in construction) The collective examination thereof; Synonym of epistemology.
EPISTEMICS n. the study of knowledge or the act of knowing.
MISTEMPERSmistempers v. Third-person singular simple present indicative form of mistemper.
MISTEMPER v. (obsolete) to temper ill; to disorder.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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