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There are 5 eight-letter words containing ISIS

CHORISISchorisis n. (Botany) The separation of a leaf (or petal or sepal) into two more parts.
CHORISIS n. (Greek) the multiplication of organs by splitting, also CHORISM.
ECCRISISeccrisis n. (Medicine, obsolete) The removal of waste.
Eccrisis prop.n. A taxonomic genus within the family Cerambycidae – certain beetles.
ECCRISIS n. expulsion of waste.
ENCLISISenclisis n. (Linguistics) The use of enclitics in the syntax of a language.
ENCLISIS n. the shifting of stress to a preceding word.
PACHISISPACHISI n. (Hindi) an Indian board game, also PARCHESI, PARCHISI.
PHTHISISphthisis n. (Archaic) An atrophy of the body or part of the body, especially pulmonary tuberculosis.
PHTHISIS n. a disease of the lungs, also PHTHISIC.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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