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There are 2 eight-letter words containing IOTO

BIOTOPESbiotopes n. Plural of biotope.
BIOTOPE n. an area having uniform conditions and supporting a particular, uniform association of animal life.
BIOTOXINbiotoxin n. Any toxin produced by a living organism.
BIOTOXIN n. a poison of biological origin.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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