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There is only one four-letter word containing IRIS

IRISiris n. (Botany) A plant of the genus Iris, common in the northern hemisphere, and generally having attractive…
iris n. (Anatomy) The contractile membrane perforated by the pupil, which adjusts to control the amount of light…
iris n. (Photography, cinematography) A diaphragm used to regulate the size of a hole, especially as a way of…

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org.

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