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There are 4 eleven-letter words containing ISAC

DISACCHARIDDISACCHARID n. any of a class of sugars, such as maltose, lactose, and sucrose, having two linked monosaccharide units per molecule.
DISACCORDEDdisaccorded v. Simple past tense and past participle of disaccord.
DISACCORD v. to refuse to assent.
DISACCREDITDISACCREDIT v. to remove accreditation from.
DISACCUSTOMdisaccustom v. To cause (someone) to break a habit or become unaccustomed to something that they are previously accustomed to.
DISACCUSTOM v. to free from a habit.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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