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There is only one six-letter word containing IOI

OPIOIDopioid n. A substance that has effects similar to opium.
opioid n. (Physiology) Any of the natural substances, such as an endorphin, released in the body in response to pain.
opioid n. (Pharmacology) Any of a group of synthetic compounds that exhibit similarities to the opium alkaloids…

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org.

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