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There are 7 four-letter words containing ISS

DISSdiss v. (North America, Britain, slang) To put (someone) down, or show disrespect by the use of insulting language…
diss n. (Slang) An insult or put-down; an expression of disrespect.
diss n. (Slang) Dissertation.
HISShiss n. A sibilant sound, such as that made by a snake or escaping steam; an unvoiced fricative.
hiss n. An expression of disapproval made using such a sound.
hiss v. (Intransitive) To make a hissing sound.
KISSkiss v. (Transitive) To touch with the lips or press the lips against, usually to show love or affection or…
kiss v. (Transitive, intransitive) To (cause to) touch lightly or slightly; to come into contact.
kiss v. (Intransitive) Of two or more people, to touch each other’s lips together, usually to express love or…
MISSmiss v. (Transitive, intransitive) To fail to hit.
miss v. (Transitive) To fail to achieve or attain.
miss v. (Transitive) To avoid; to escape.
PISSpiss n. (Now vulgar slang, usually uncountable) Urine.
piss n. (Vulgar, slang, countable) The act of urinating.
piss n. (Vulgar, slang, countable and uncountable) Alcoholic beverage, especially of inferior quality.
SISSsiss n. (US, colloquial) A hissing noise.
siss v. (US, colloquial, intransitive) To make a hissing sound.
SISS n. (short for) sister, also SIS.
WISSwiss v. (Archaic) To know; to understand.
Wiss prop.n. A surname from German.
WISS v. to wish.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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