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There are 2 four-letter words containing ISC

DISC	• disc n. A thin, flat, circular plate or similar object. • disc n. (Anatomy) An intervertebral disc. • disc n. Something resembling a disc.
FISC	• fisc n. (Ancient Rome) The public treasury of Rome. • fisc n. Any state treasury or exchequer. • FISC n. (obsolete) the state treasury; the public revenue, also FISK.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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English Wiktionary: 14 words
Scrabble in French: 1 word
Scrabble in Spanish: no word
Scrabble in Italian: 1 word
Scrabble in German: 1 word
Scrabble in Romanian: 6 words

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