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There are 13 twelve-letter words containing FEN

CODEFENDANTScodefendants n. Plural of codefendant.
co-defendants n. Plural of co-defendant.
CODEFENDANT n. a joint defendant.
DEFENESTRATEdefenestrate v. (Transitive) To eject or throw (someone or something) from or through a window.
defenestrate v. (Transitive) To throw out; to remove or dismiss (someone) from a position of power or authority.
defenestrate v. (Computing, transitive, humorous, slang) To remove a Windows operating system from a computer.
DEFENSATIVESdefensatives n. Plural of defensative.
DEFENSATIVE n. a protection.
FENESTRATINGfenestrating v. Present participle of fenestrate.
FENESTRATE v. to equip with windows.
FENESTRATIONfenestration n. (Architecture) The arrangement of windows and similar openings in a building.
fenestration n. (Surgery, anatomy) An opening in the surface of an organ etc; the surgical creation of such an opening…
fenestration n. (Surgery, anatomy) An opening that occurs naturally or is created surgically, as through a biological membrane.
FENFLURAMINEfenfluramine n. An appetite suppressant used to treat obesity.
FENNELFLOWERfennelflower n. Nigella sativa, an annual flowering plant native to south and southwest Asia.
fennelflower n. Nigella damascena, ragged lady.
FENNELFLOWER n. any of various species of the plant nigella with finely-divided leaves.
HALFENDEALESHALFENDEALE n. (Spenser) half.
INDEFENSIBLEindefensible adj. Not defensible; not capable of being defended.
indefensible adj. Incapable of being justified or excused.
indefensible adj. Incapable of being explained.
INDEFENSIBLYindefensibly adv. In an indefensible manner.
INDEFENSIBLE adv. incapable of being maintained as right or valid.
OFFENDRESSESoffendresses n. Plural of offendress.
OFFENDRESS n. (Shakespeare) a female offender.
UNSAFENESSESUNSAFENESS n. the state of being unsafe.
UNSTIFFENINGunstiffening v. Present participle of unstiffen.
UNSTIFFEN v. to make not stiff.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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