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There are 3 twelve-letter words containing ESTANT

DECONGESTANTdecongestant n. A drug that relieves congestion, e.g. pseudoephedrine.
DECONGESTANT n. an agent that relieves congestion (as of mucous membranes).
DISINFESTANTdisinfestant n. A substance used to eliminate pests.
DISINFESTANT n. an agent that disinfests, rids of vermin.
MANIFESTANTSmanifestants n. Plural of manifestant.
MANIFESTANT n. a person who makes or participates in a manifestation.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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