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There are 12 twelve-letter words containing ESPI

CAESPITOSELYCAESPITOSE adv. growing in clusters or tufts.
DESPISEDNESSdespisedness n. The state or quality of being despised.
DESPISEDNESS n. (Milton) the state of being despised.
DESPISEMENTSdespisements n. Plural of despisement.
DESPISEMENT n. the act of despising.
DESPITEFULLYdespitefully adv. (Archaic) In a despiteful manner; spitefully.
DESPITEFUL adv. (archaic) full of despite, malicious.
DESPITEOUSLYdespiteously adv. In a despiteous manner.
DESPITEOUS adv. (obsolete) feeling or showing despite.
ESPIEGLERIESespiegleries n. Plural of espieglerie.
ESPIEGLERIE n. (French) the quality of being espiegle, roguish.
IRRESPIRABLEirrespirable adj. Unbreathable.
IRRESPIRABLE adj. unfit for respiration.
MARLINESPIKEmarlinespike n. Alternative spelling of marlinspike.
marline␣spike n. Alternative spelling of marlinspike.
MARLINESPIKE n. a tool used to separate rope strands while splicing, also MARLINGSPIKE, MARLINSPIKE.
RESPIRATIONSrespirations n. Plural of respiration.
RESPIRATION n. breathing; the taking in of oxygen and giving out of carbon dioxide.
RESPIROMETERrespirometer n. A device used to measure the rate of respiration of living organisms, such as plants or fish.
respirometer n. An apparatus for supplying air to a diver under water.
RESPIROMETER n. an instrument for measuring and studying respiration.
RESPIROMETRYrespirometry n. A form of calorimetry that is used to measure the metabolic rate.
RESPIROMETRY n. measurement by respirometer.
SYNTHESPIANSsynthespians n. Plural of synthespian.
SYNTHESPIAN n. a computer-generated image of a film actor used in place of the actor when filming stunts.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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