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There are 13 twelve-letter words containing EFRA

DEFRAGMENTEDdefragmented v. Simple past tense and past participle of defragment.
DEFRAGMENT v. to run a program which reduces or eliminates the fragmentation of (a file or disk) by bringing together parts of files stored in separate locations to a single location on the disk.
DEFRAGMENTERdefragmenter n. (Computing) That which defragments; a program that performs defragmentation.
DEFRAUDATIONdefraudation n. (Obsolete) The act of defrauding; a taking by fraud.
DEFRAUDATION n. the act of defrauding.
DEFRAUDMENTSdefraudments n. Plural of defraudment.
DEFRAUDMENT n. the act of defrauding.
IRREFRAGABLEirrefragable adj. Which cannot be refuted; clearly right, incontrovertible, indisputable, irrefutable.
irrefragable adj. (Archaic) Which cannot or should not be broken; indestructible.
irrefragable adj. (Obsolete) Of a person: obstinate, stubborn.
IRREFRAGABLYirrefragably adv. In an irrefragable state or condition.
IRREFRAGABLE adv. impossible to refute or dispute.
REFRACTARIESREFRACTARY n. a substance that is able to resist high temperatures, etc., used in lining furnaces, etc.
REFRACTIVELYrefractively adv. In a refractive manner.
refractively adv. By means of refraction.
REFRACTIVE adv. serving to refract.
REFRACTIVITYrefractivity n. The quality or degree of being refractive.
REFRACTIVITY n. the state of being refractive.
REFRACTORIESrefractories n. Plural of refractory.
REFRACTORY n. a stubborn person.
REFRACTORILYrefractorily adv. In a refractory manner.
REFRACTORY adv. unruly, stubborn.
REFRACTURINGrefracturing v. Present participle of refracture.
REFRACTURE v. to fracture again.
REFRAINMENTSrefrainments n. Plural of refrainment.
REFRAINMENT n. the act of refraining.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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