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There are 4 words containing ESPONSIBLE

IRRESPONSIBLE	• irresponsible adj. (Now rare) Not responsible; exempt from legal responsibility, not to be held accountable. • irresponsible adj. Lacking a sense of responsibility; performed or acting as though without responsibility; negligent. • irresponsible n. Someone who is not responsible.
IRRESPONSIBLES	• irresponsibles n. Plural of irresponsible. • IRRESPONSIBLE n. a person who is irresponsible.
RESPONSIBLE	• responsible adj. (Postpositive, followed by "for") Having the duty of taking care of something; answerable for an act… • responsible adj. (Postpositive, followed by "for") Being a primary cause of a situation or action and thus able to be… • responsible adj. (Followed by "to") Answerable to (a superior).
RESPONSIBLENESS	• responsibleness n. The state of being responsible; responsibility. • RESPONSIBLENESS n. the state of being responsible.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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English Wiktionary: 13 words
Scrabble in French: no word
Scrabble in Spanish: no word
Scrabble in Italian: no word
Scrabble in German: no word
Scrabble in Romanian: no word

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