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There are 4 twelve-letter words containing DESTRU

AUTODESTRUCTautodestruct v. (Intransitive, chiefly science fiction) To destroy itself by design (as of a mechanical system).
autodestruct n. (Chiefly science fiction) A feature of a system whereby it destroys itself.
AUTODESTRUCT v. to self-destruct.
DESTRUCTIBLEdestructible adj. Liable to destruction; capable of being destroyed.
DESTRUCTIBLE adj. capable of being destroyed.
DESTRUCTIONSdestructions n. Plural of destruction.
DESTRUCTION n. the state or fact of being destroyed.
DESTRUCTIVESDESTRUCTIVE n. something destructive.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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