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There are 5 twelve-letter words containing DEFEN

CODEFENDANTScodefendants n. Plural of codefendant.
co-defendants n. Plural of co-defendant.
CODEFENDANT n. a joint defendant.
DEFENESTRATEdefenestrate v. (Transitive) To eject or throw (someone or something) from or through a window.
defenestrate v. (Transitive) To throw out; to remove or dismiss (someone) from a position of power or authority.
defenestrate v. (Computing, transitive, humorous, slang) To remove a Windows operating system from a computer.
DEFENSATIVESdefensatives n. Plural of defensative.
DEFENSATIVE n. a protection.
INDEFENSIBLEindefensible adj. Not defensible; not capable of being defended.
indefensible adj. Incapable of being justified or excused.
indefensible adj. Incapable of being explained.
INDEFENSIBLYindefensibly adv. In an indefensible manner.
INDEFENSIBLE adv. incapable of being maintained as right or valid.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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